ORM:1, Hand Coding:0
Alexey has an interesting story about big cost saving (money, time, simpler architecture) NHibernate has enabled for his team.
I recall doing an integration project once where I was able to move the database from an intermediatory SQL Server to DB2 on AS400 by changing a few lines in the configuration files (the client decided not to go with the approach, though, since it didn't fit their ESB plans).
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